Glycolysis and glyconeogenesis play crucial roles in the ATP supply and synthesis of
glycoconjugates, important for the viability and virulence, respectively, of the human …

A mathematical model of glycolysis in bloodstream form Trypanosoma brucei was
developed previously on the basis of all available enzyme kinetic data (Bakker, BM, Michels …

Systems analyses have facilitated the characterization of metabolic networks of several
organisms. We have reconstructed the metabolic network of Leishmania major, a poorly …

The multifunctional protein enolase has repeatedly been identified on the surface of
numerous cell types, including a variety of pathogenic microorganisms. In Candida albicans …

Bloodstream form African trypanosomes are thought to rely exclusively upon glycolysis,
using glucose as a substrate, for ATP production. Indeed, the pathway has long been …

Male infertility is common and complex, presenting a wide range of heterogeneous
phenotypes. Although about 50% of cases are estimated to have a genetic component, the …

Paracoccidioidomycosis is a systemic mycosis caused by the dimorphic fungus
Paracoccidioides brasiliensis. Understanding the interactions between P. brasiliensis and …

Mitochondrial ATP synthase is a reversible nanomotor synthesizing or hydrolyzing ATP
depending on the potential across the membrane in which it is embedded. In the unicellular …

In the infectious stage of Trypanosoma brucei, an important parasite of humans and
livestock, the mitochondrial (mt) membrane potential (Δψm) is uniquely maintained by the …

We have cloned, over‐expressed and purified enolase from Plasmodium falciparum strain
NF54 in Escherichia coli in active form, as an N‐terminal His6‐tagged protein. The …