The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor
that has multiple accessory functions during viral infection. In recent years, the major role …

The world is currently undergoing a pandemic caused by an H1N1 influenza A virus, the so-
called'swine flu'. The H5N1 ('bird flu') influenza A viruses, now circulating in Asia, Africa and …

The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal
CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production …

The retinoic acid-inducible gene I product (RIG-I) has been identified as a cellular sensor of
RNA virus infection resulting in beta interferon (IFN-β) induction. However, many viruses are …

The replication and pathogenicity of influenza A virus (FLUAV) are controlled in part by the
alpha/beta interferon (IFN-α/β) system. This virus-host interplay is dependent on the …

It is not known how influenza A viruses, important human pathogens, counter PKR
activation, a crucial host antiviral response. Here we elucidate this mechanism. We show …

The non-structural protein 1 of influenza virus (NS1) is a relatively small polypeptide with an
outstanding number of ascribed functions. NS1 is the main viral antagonist of the innate …

Influenza A virus NS1 is a multifunctional protein, and in virus-infected cells NS1 modulates
a number of host-cell processes by interacting with cellular factors. Here, we report that NS1 …

Little is known about the processes that enable influenza A viruses to jump into new host
species. Here we show that the non-structural protein1 nucleotide substitution, A374G …

Most viruses express one or several proteins that counter the antiviral defences of the host
cell. This is the task of non-structural protein NS1 in influenza viruses. Absent in the viral …