Background Antibiotics are the most common medicines prescribed to children in hospitals
and the community, with a high proportion of potentially inappropriate use. Antibiotic misuse …

Antimicrobial dosing in the intensive care unit (ICU) can be problematic due to various
challenges including unique physiological changes observed in critically ill patients and the …

Background Model-informed precision dosing (MIPD) can serve as a powerful tool during
therapeutic drug monitoring (TDM) to help individualize dosing in populations with large …

Background Vancomycin optimization is challenging, requiring careful therapeutic drug
monitoring (TDM) to avoid toxicity and ensure an efficacious concentration. Most …

Background Vancomycin is one of the commonly used anti-microbial drugs in intensive care
units (ICUs). Guidelines recommend maintaining therapeutic trough levels of vancomycin …

Background: Vancomycin has been a first-line treatment for Gram-positive infections for
decades. However, strategies for therapeutic drug monitoring (TDM) and dose-optimization …

Aims and objectives Vancomycin is a drug of choice for various gram-positive bacterial
(GPB) infections and is largely prescribed to pediatric intensive care unit (PICU) patients …

OBJECTIVES Antimicrobial stewardship programs (ASPs) restrict prescribing practices to
regulate antimicrobial use, increasing the risk of prescribing errors. This quality improvement …

Vancomycin is a glycopeptide antibiotic used for the treatment of Gram-positive infections.
For adult patients, treatment with vancomycin requires effective therapeutic drug-monitoring …

Background Higher doses of vancomycin are currently prescribed due to the emergence of
bacterial tolerance and resistance. This study aimed to evaluate the efficacy and safety of …