The chick embryo chorioallantoic membrane as a model for tumor biology
D Ribatti - Experimental cell research, 2014 - Elsevier
Among the in vivo models, the chick embryo chorioallantoic membrane (CAM) has been
used to implant several tumor types as well as malignant cell lines to study their growth rate …
used to implant several tumor types as well as malignant cell lines to study their growth rate …
How I treat patients who mobilize hematopoietic stem cells poorly
LB To, JP Levesque, KE Herbert - Blood, The Journal of the …, 2011 - ashpublications.org
Abstract Transplantation with 2-5× 106 mobilized CD34+ cells/kg body weight lowers
transplantation costs and mortality. Mobilization is most commonly performed with …
transplantation costs and mortality. Mobilization is most commonly performed with …
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
Thalidomide and the immunomodulatory drug, lenalidomide, are therapeutically active in
hematological malignancies. The ubiquitously expressed E3 ligase protein cereblon …
hematological malignancies. The ubiquitously expressed E3 ligase protein cereblon …
Elotuzumab enhances natural killer cell activation and myeloma cell killing through interleukin-2 and TNF-α pathways
B Balasa, R Yun, NA Belmar, M Fox, DT Chao… - Cancer immunology …, 2015 - Springer
Elotuzumab is a humanized monoclonal antibody specific for signaling lymphocytic
activation molecule-F7 (SLAMF7, also known as CS1, CD319, or CRACC) that enhances …
activation molecule-F7 (SLAMF7, also known as CS1, CD319, or CRACC) that enhances …
Blocking the FGF/FGFR system as a⿿ two-compartment⿿ antiangiogenic/antitumor approach in cancer therapy
Fibroblast growth factors (FGFs) are a family of pleiotropic factors produced by stromal and
parenchymal tumor cells. Even though FGFs have been firstly characterized as angiogenic …
parenchymal tumor cells. Even though FGFs have been firstly characterized as angiogenic …
New insights in anti-angiogenesis in multiple myeloma
Angiogenesis is a constant hallmark of multiple myeloma (MM) progression and involves
direct production of angiogenic cytokines by plasma cells and their induction within the bone …
direct production of angiogenic cytokines by plasma cells and their induction within the bone …
Insight into the role of Wnt5a-induced signaling in normal and cancer cells
M Endo, M Nishita, M Fujii, Y Minami - … review of cell and molecular biology, 2015 - Elsevier
Wnt5a is involved in the activation of noncanonical Wnt signaling, including planar cell
polarity (PCP) and Wnt-Ca 2+ pathways. The Ror-family of receptor tyrosine kinases is …
polarity (PCP) and Wnt-Ca 2+ pathways. The Ror-family of receptor tyrosine kinases is …
[HTML][HTML] Possible biological and translational significance of mast cells density in colorectal cancer
I Marech, M Ammendola, C Gadaleta… - World journal of …, 2014 - ncbi.nlm.nih.gov
Mast cells (MCs), located ubiquitously near blood vessels, are descended from CD34+
hematopoietic stem cells. Initially, although their role has been well defined in …
hematopoietic stem cells. Initially, although their role has been well defined in …
A HGF/cMET autocrine loop is operative in multiple myeloma bone marrow endothelial cells and may represent a novel therapeutic target
A Ferrucci, M Moschetta, MA Frassanito, S Berardi… - Clinical cancer …, 2014 - AACR
Purpose: The aim of this study was to investigate the angiogenic role of the hepatocyte
growth factor (HGF)/cMET pathway and its inhibition in bone marrow endothelial cells (EC) …
growth factor (HGF)/cMET pathway and its inhibition in bone marrow endothelial cells (EC) …
[HTML][HTML] Inhibition of mTOR complex 2 restrains tumor angiogenesis in multiple myeloma
A Lamanuzzi, I Saltarella, V Desantis, MA Frassanito… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Abstract The mammalian Target of Rapamycin (mTOR) is an intracellular serine/threonine
kinase that mediates intracellular metabolism, cell survival and actin rearrangement. mTOR …
kinase that mediates intracellular metabolism, cell survival and actin rearrangement. mTOR …