PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …

Autophagy, lipophagy, and mitophagy are considered to be the major recycling processes
for protein aggregates, excess fat, and damaged mitochondria in adipose tissues in …

Adequate mass and function of adipose tissues (ATs) play essential roles in preventing
metabolic perturbations. The pathological reduction of ATs in lipodystrophy leads to an array …

Objective Beclin1 is a core molecule of the macroautophagy machinery. Although
dysregulation of macroautophagy is known to be involved in metabolic disorders, the …

Simple Summary In male animals, heat stress causes injury to the testes, resulting in an
increase in the number of deformed sperm, a reduction in testosterone production, and …

Transcriptional elongation is a universal and critical step during gene expression. The super
elongation complex (SEC) regulates the rapid transcriptional induction by mobilizing paused …

Background To investigate effects of metformin on the regulation of proteins of white adipose
tissue (WAT) and brown adipose tissue (BAT) in obesity and explore the underlying …

Heat stress has been documented to reduce reproductive performance of female animals
through injury to germ cells, with few studies available in male animals. The objectives of …

Cervical cancer is a worldwide public health problem, and improved selective therapies and
anticancer drugs are urgently needed. In recent years, emodin has attracted considerable …

Obesity is associated with energy metabolic disturbance and is caused by long-term
excessive energy storage in white adipose tissue (WAT). The WAT browning potentially …