Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …

The human genome encodes probably more than 20 different sialyltransferases involved in
the biosynthesis of sialylated glycoproteins and glycolipids but to date only 15 different …

The Siglecs (sialic acid-binding immunoglobulin-like lectins) are glycoimmune checkpoint
receptors that suppress immune cell activation upon engagement of cognate sialoglycan …

Mutations in the gene encoding the glycosyltransferase polypeptide GalNAc-T3, which is
involved in initiation of O-glycosylation, were recently identified as a cause of the rare …

It has long been known that cancer cells often express more heavily sialylated glycans on
their surface and that this feature sometimes correlates with invasion. It is now well …

Abstract The Sialyl-Tn antigen (Neu5Acα2–6GalNAc-O-Ser/Thr) is highly expressed in
several human carcinomas and is associated with carcinoma aggressiveness and poor …

Human airway mucins represent a very broad family of polydisperse high molecular mass
glycoproteins, which are part of the airway innate immunity. Apomucins, which correspond to …

Background The ability to selectively detect and target cancer cells that have undergone an
epithelial-mesenchymal transition (EMT) may lead to improved methods to treat cancers …

Introduction 3. Human ST involved in the synthesis of sialylated TACA 3.1. The β-
galactoside α2, 3-sialyltransferases (ST3Gal) 3.2. The β-galactoside α2, 6-sialyltransferases …

All cells are decorated with complex carbohydrate structures called glycans that serve as
ligands for glycan-binding proteins (GBPs) to mediate a wide range of biological processes …