Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

CD8 T cells require a third signal, along with Ag and costimulation, to make a productive
response and avoid death and/or tolerance induction. Recent studies indicate that IL-12 and …

Antigen-experienced memory T cells acquire effector function with innate-like kinetics;
however, the metabolic requirements of these cells are unknown. Here we show that rapid …

It is now convincingly clear that diet is one of the most influential lifestyle factors contributing
to the rise of inflammatory diseases and autoimmunity in both developed and developing …

Immune protection and lasting memory are accomplished through the generation of
phenotypically and functionally distinct CD8 T cell subsets. Understanding how these …

How the immune system remembers a previous encounter with a pathogen and responds
more efficiently to a subsequent encounter has been one of the central enigmas for …

Memory lymphocytes are characterized by their ability to exhibit a rapid response to the
recall antigen, in which differential transcription is important, yet the underlying mechanism …

Immune-mediated diseases are clinically heterogeneous but they share genetic and
pathogenic mechanisms. These diseases may develop from the interplay of genetic factors …

A third signal that can be provided by IL-12 or type I IFN is required for differentiation of
naive CD8 T cells responding to Ag and costimulation. The cytokines program development …

To understand the mechanism regulating the effector function of memory CD8 T cells, we
examined expression and chromatin state of a key transcription factor (eomesodermin …