The microbiome–gut–brain axis in Parkinson disease—from basic research to the clinic

AH Tan, SY Lim, AE Lang - Nature Reviews Neurology, 2022 - nature.com
Evidence for a close bidirectional link between the brain and the gut has led to a paradigm
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …

The gut microbiota–brain axis in behaviour and brain disorders

LH Morais, HL Schreiber IV… - Nature Reviews …, 2021 - nature.com
In a striking display of trans-kingdom symbiosis, gut bacteria cooperate with their animal
hosts to regulate the development and function of the immune, metabolic and nervous …

Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms

ZD Wallen, A Demirkan, G Twa, G Cohen… - Nature …, 2022 - nature.com
Parkinson's disease (PD) may start in the gut and spread to the brain. To investigate the role
of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using …

Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease

P Kesika, N Suganthy, BS Sivamaruthi, C Chaiyasut - Life sciences, 2021 - Elsevier
Gut microbiota represents a diverse and dynamic population of microorganisms harboring
the gastrointestinal tract, which influences the host health and disease. Gut microbiota …

Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Gut microbial molecules in behavioural and neurodegenerative conditions

BD Needham, R Kaddurah-Daouk… - Nature Reviews …, 2020 - nature.com
Mounting evidence suggests that the gut microbiome impacts brain development and
function. Gut–brain connections may be mediated by an assortment of microbial molecules …

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

C Soto, S Pritzkow - Nature neuroscience, 2018 - nature.com
A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

[HTML][HTML] Brain-gut-microbiota axis in Alzheimer's disease

K Kowalski, A Mulak - Journal of neurogastroenterology and …, 2019 - ncbi.nlm.nih.gov
Disturbances along the brain-gut-microbiota axis may significantly contribute to the
pathogenesis of neurodegenerative disorders. Alzheimer's disease (AD) is the most frequent …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

TR Sampson, C Challis, N Jain, A Moiseyenko… - elife, 2020 - elifesciences.org
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases …