Background Although great achievements have been made in the field of cancer therapy,
chemotherapy and radiotherapy remain the mainstay cancer therapeutic modalities …

Extensive research over the past half a century indicates that reactive oxygen species (ROS)
play an important role in cancer. Although low levels of ROS can be beneficial, excessive …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Spiral ganglion neurons (SGNs) are auditory neurons that relay sound signals from the inner
ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to …

Evidence of significant hearing loss during the early days of use of cisplatin as a
chemotherapeutic agent in cancer patients has stimulated research into the causes and …

Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and
ototoxic side-effects remain major clinical limitations. Recent studies have improved our …

The platinum-based drugs cisplatin, carboplatin, and oxaliplatin belong to the most widely
used chemotherapeutics in oncology, showing clinical efficacy against many solid tumors …

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which
mediate the physiological actions of adenosine. To date, four AR subtypes have been …

Hearing loss is a significant health problem that can result from a variety of exogenous
insults that generate oxidative stress and inflammation. This can produce cellular damage …

Abstract The Signal Transducer and Activator of Transcription (STAT) family of proteins
consists of transcription factors that play a complex and essential role in the regulation of …