The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …

The circadian clock controls several aspects of mammalian physiology and orchestrates the
daily oscillations of biological processes and behavior. Our circadian rhythms are driven by …

Aging is characterized by an increased vulnerability to infection and the development of
inflammatory diseases, such as atherosclerosis, frailty, cancer and neurodegeneration …

Obesity and liver diseases are associated with the disruption of the circadian clock that
orchestrates mammalian physiology to optimize nutrient metabolism and storage. Here, we …

An emerging role for the circadian clock in autophagy and lysosome function has opened
new avenues for exploration in the field of neurodegeneration. The daily rhythms of …

The challenge of wound infections post-surgery and open trauma caused by multidrug-
resistant bacteria poses a constant threat to clinical treatment. As a promising antimicrobial …

The immune system is built to counteract unpredictable threats, yet it relies on predictable
cycles of activity to function properly. Daily rhythms in immune function are an expanding …

Microglia play a critical role in maintaining neural function. While microglial activity follows a
circadian rhythm, it is not clear how this intrinsic clock relates to their function, especially in …

Circadian biology modulates almost all aspects of mammalian physiology, disease, and
response to therapies. Emerging data suggest that circadian biology may significantly affect …

Patients admitted to the intensive care unit (ICU) are in need of continuous organ
replacement strategies and specialized care, for example because of neurological …