In animals, systemic control of metabolism is conducted by metabolic tissues and relies on
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …

Metabolic syndrome is a cluster of metabolic risk factors, characterized by abdominal
obesity, dyslipidemia, low levels of high-density lipoprotein cholesterol (HDL-c) …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

It is well-known that obesity is a complex multifactorial and heterogeneous condition with an
important genetic component. Recently, major advances in obesity research emerged …

Candidate gene and genome-wide association studies have led to the discovery of nine loci
involved in Mendelian forms of obesity and 58 loci contributing to polygenic obesity. These …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …

Positive selection in Europeans at the 2q21. 3 locus harboring the lactase gene has been
attributed to selection for the ability of adults to digest milk to survive famine in ancient times …

Objective An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is
critical for improving precision prevention, including individualized screening …

Background: High dairy/milk intake has been associated with a low risk of type 2 diabetes
observationally, but whether this represents a causal association is unknown. Objective: We …