Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Multi-omics integration in biomedical research–A metabolomics-centric review

MA Wörheide, J Krumsiek, G Kastenmüller… - Analytica chimica …, 2021 - Elsevier
Recent advances in high-throughput technologies have enabled the profiling of multiple
layers of a biological system, including DNA sequence data (genomics), RNA expression …

[HTML][HTML] Anti-oxidant and anti-inflammatory activity of ketogenic diet: new perspectives for neuroprotection in Alzheimer's disease

A Pinto, A Bonucci, E Maggi, M Corsi, R Businaro - Antioxidants, 2018 - mdpi.com
The ketogenic diet, originally developed for the treatment of epilepsy in non-responder
children, is spreading to be used in the treatment of many diseases, including Alzheimer's …

Computational approaches for network-based integrative multi-omics analysis

FE Agamah, JR Bayjanov, A Niehues… - Frontiers in Molecular …, 2022 - frontiersin.org
Advances in omics technologies allow for holistic studies into biological systems. These
studies rely on integrative data analysis techniques to obtain a comprehensive view of the …

Metabolomics and multi-omics integration: a survey of computational methods and resources

T Eicher, G Kinnebrew, A Patt, K Spencer, K Ying, Q Ma… - Metabolites, 2020 - mdpi.com
As researchers are increasingly able to collect data on a large scale from multiple clinical
and omics modalities, multi-omics integration is becoming a critical component of …

Stability of person-specific blood-based infrared molecular fingerprints opens up prospects for health monitoring

M Huber, KV Kepesidis, L Voronina, M Božić… - Nature …, 2021 - nature.com
Health state transitions are reflected in characteristic changes in the molecular composition
of biofluids. Detecting these changes in parallel, across a broad spectrum of molecular …

Fast and deep diagnosis using blood-based ATR-FTIR spectroscopy for digestive tract cancers

S Guo, G Wei, W Chen, C Lei, C Xu, Y Guan, T Ji… - Biomolecules, 2022 - mdpi.com
Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) of liquid
biofluids enables the probing of biomolecular markers for disease diagnosis, characterized …

Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19

M Tomazou, MM Bourdakou, G Minadakis… - Briefings in …, 2021 - academic.oup.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is
undeniably the most severe global health emergency since the 1918 Influenza outbreak …

[HTML][HTML] A guide to multi-omics data collection and integration for translational medicine

E Athieniti, GM Spyrou - Computational and Structural Biotechnology …, 2023 - Elsevier
The emerging high-throughput technologies have led to the shift in the design of
translational medicine projects towards collecting multi-omics patient samples and …

Deciphering crucial genes in multiple sclerosis pathogenesis and drug repurposing: A systems biology approach

S Dadashkhan, SA Mirmotalebisohi, H Poursheykhi… - Journal of …, 2023 - Elsevier
This study employed systems biology and high-throughput technologies to analyze complex
molecular components of MS pathophysiology, combining data from multiple omics sources …