There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …

Background Lung diseases including chronic obstructive pulmonary disease (COPD),
infections like influenza, acute respiratory distress syndrome (ARDS), asthma and …

Tissue development is orchestrated by the coordinated activities of both chemical and
physical regulators. While much attention has been given to the role that chemical regulators …

Dynamic remodeling of the extracellular matrix (ECM) is essential for development, wound
healing and normal organ homeostasis. Life-threatening pathological conditions arise when …

Human tissues must be elastic, much like other materials that work under continuous loads
without losing functionality. The elasticity of tissues is provided by elastin, a unique protein of …

The cells and tissues of the human body are constantly exposed to exogenous and
endogenous forces that are referred to as biomechanical cues. They guide and impact …

The extracellular matrix is an integral and dynamic component of all tissues.
Macromolecular compositions and structural architectures of the matrix are tissue-specific …

With mathematical and computational models furthering our understanding of lung
mechanics, function and disease, this book provides an all-inclusive introduction to the topic …

Changes in extracellular matrix (ECM) components in the lungs are associated with the
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …

We report here the first attempt to produce and use whole acellular (AC) lung as a matrix to
support development of engineered lung tissue from murine embryonic stem cells (mESCs) …