Recent development of aryl diazonium chemistry for the derivatization of aromatic compounds

F Mo, D Qiu, L Zhang, J Wang - Chemical Reviews, 2021 - ACS Publications
Aryl diazonium salts are versatile building blocks in organic synthesis. In light of the ever-
increasing importance of aryl diazonium salts spanning most disciplines of the chemical …

Flow reactors integrated with in-line monitoring using benchtop NMR spectroscopy

P Giraudeau, FX Felpin - Reaction Chemistry & Engineering, 2018 - pubs.rsc.org
The monitoring of chemical reactions on the fly conducted in flow through the use of
benchtop NMR spectroscopy is an emerging field of research allowing tremendous …

The evolution of high-throughput experimentation in pharmaceutical development and perspectives on the future

SM Mennen, C Alhambra, CL Allen… - … Process Research & …, 2019 - ACS Publications
High-throughput experimentation (HTE) has revolutionized the pharmaceutical industry,
most notably allowing for rapid screening of compound libraries against therapeutic targets …

Electrochemical activation of diverse conventional photoredox catalysts induces potent photoreductant activity

CP Chernowsky, AF Chmiel… - Angewandte Chemie …, 2021 - Wiley Online Library
Herein, we disclose that electrochemical stimulation induces new photocatalytic activity from
a range of structurally diverse conventional photocatalysts. These studies uncover a new …

Visible light photocatalysis: applications and new disconnections in the synthesis of pharmaceutical agents

JJ Douglas, MJ Sevrin… - … Process Research & …, 2016 - ACS Publications
Photoredox catalysis has emerged as a powerful tool for the synthetic chemist to access
challenging targets and to generate new structural complexity. This review focuses on the …

A need for caution in the preparation and application of synthetically versatile aryl diazonium tetrafluoroborate salts

JD Firth, IJS Fairlamb - Organic Letters, 2020 - ACS Publications
Since their discovery 1 in 1858, aryl diazonium salts have played a major role in organic
synthesis. They have been widely employed as precursors to diazo dyes 2 and synthetic …

An autonomous self-optimizing flow reactor for the synthesis of natural product carpanone

D Cortés-Borda, E Wimmer, B Gouilleux… - The Journal of …, 2018 - ACS Publications
A modular autonomous flow reactor combining monitoring technologies with a feedback
algorithm is presented for the synthesis of the natural product carpanone. The autonomous …

Comparison of the thermal stabilities of diazonium salts and their corresponding triazenes

C Schotten, SK Leprevost, LM Yong… - … Process Research & …, 2020 - ACS Publications
A range of diazonium salts and their corresponding triazenes have been prepared in order
to directly compare their relative thermal stabilities (via initial decomposition temperature) …

Aryl Diazonium Salt‐Triggered Cyclization and Cycloaddition Reactions: Past, Present, and Future

FG Zhang, Z Chen, CW Cheung… - Chinese Journal of …, 2020 - Wiley Online Library
Aryl diazonium salts occupy a privileged role in synthetic chemistry owing to their ready
availability and versatile reactivity. While their applications in accessing diversely …

Optimizing the Heck–Matsuda reaction in flow with a constraint-adapted direct search algorithm

D Cortés-Borda, KV Kutonova, C Jamet… - … Process Research & …, 2016 - ACS Publications
The optimization of a palladium-catalyzed Heck–Matsuda reaction using an optimization
algorithm is presented. We modified and implemented the Nelder–Mead method in order to …