Proteoglycans are vital components of the extracellular matrix in articular cartilage, providing
biomechanical properties crucial for its proper functioning. They are key players in chondral …

Biological tissues are not uniquely composed of cells. A substantial part of their volume is
extracellular space, which is primarily filled by an intricate network of macromolecules …

A key aim in epidemiological neuroscience is identification of markers to assess brain health
and monitor therapeutic interventions. Quantitative susceptibility mapping (QSM) is an …

Ancient genomes provide a tool to investigate the genetic basis of adaptations in extinct
organisms. However, the identification of species-specific fixed genetic variants requires the …

Stroke is the second leading cause of death worldwide and has two major subtypes:
ischemic stroke and hemorrhagic stroke. Neuroinflammation is a pathological hallmark of …

Proteoglycans are composite molecules comprising a protein backbone, ie, the core protein,
with covalently attached glycosaminoglycan chains of distinct chemical types. Most …

The uterus, a vital organ in the female reproductive system, nurtures and supports
developing embryos until maturity. This study focuses on addressing uterine related …

Chondroitin sulfate (CS) is the most abundant and widely distributed glycosaminoglycan
(GAG) in the human body. As a component of proteoglycans (PGs) it has numerous roles in …

The extracellular matrix (ECM) is an active and dynamic feature of tissues that not only
provides gross structure but also plays key roles in cellular responses. The ever-changing …

Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the
extracellular matrix. They share the same structural domains at both N-and C-termini. The N …