During pregnancy, the mother must adapt her body systems to support nutrient and oxygen
supply for growth of the baby in utero and during the subsequent lactation. These include …

Estrogen is a potent steroid with pleiotropic effects, which have yet to be fully elucidated.
Estrogen has both nuclear and non-nuclear effects. The rapid response to estrogen, which …

Although the pathobiology of atherosclerosis is a complex multifactorial process, blood flow-
induced shear stress has emerged as an essential feature of atherogenesis. This fluid drag …

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage
of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of …

Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of
maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily …

BACKGROUND Estrogens regulate disparate female physiological processes, thus
ensuring reproduction. Altered estrogen levels and signaling have been associated with …

The greater incidence of hypertension and coronary artery disease in men and
postmenopausal women compared with premenopausal women has been related, in part, to …

Pregnancy outcomes in patients with pulmonary hypertension remain poor despite
advanced therapies. Although consensus guidelines recommend against pregnancy in …

Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

To evaluate the role of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in breast cancer
cell survival and therapeutic resistance, we analyzed a panel of six breast cancer cell lines …