Connective tissue growth factor: from molecular understandings to drug discovery

Z Chen, N Zhang, HY Chu, Y Yu, ZK Zhang… - Frontiers in cell and …, 2020 - frontiersin.org
Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved
in different biological processes, such as cell proliferation, angiogenesis, and wound …

[HTML][HTML] A comprehensive overview of graph neural network-based approaches to clustering for spatial transcriptomics T. Liu et al. Overview of Spatial Transcriptomics …

T Liu, ZY Fang, Z Zhang, Y Yu, M Li, MZ Yin - Computational and Structural …, 2023 - Elsevier
Spatial transcriptomics technologies enable researchers to accurately quantify and localize
messenger ribonucleic acid (mRNA) transcripts at a high resolution while preserving their …

A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice

A Bilkei-Gorzo, O Albayram, A Draffehn, K Michel… - Nature medicine, 2017 - nature.com
The balance between detrimental, pro-aging, often stochastic processes and counteracting
homeostatic mechanisms largely determines the progression of aging. There is substantial …

Therapeutic strategies to target connective tissue growth factor in fibrotic lung diseases

T Isshiki, S Naiel, M Vierhout, K Otsubo, P Ali… - Pharmacology & …, 2023 - Elsevier
The treatment of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF),
remains challenging as current available antifibrotic agents are not effective in halting …

Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions

S Kubota, M Takigawa - Clinical science, 2015 - portlandpress.com
CCN family protein 2 (CCN2), also widely known as connective tissue growth factor (CTGF),
is one of the founding members of the CCN family of matricellular proteins. Extensive …

Neuronal survival in the brain: neuron type-specific mechanisms

U Pfisterer, K Khodosevich - Cell death & disease, 2017 - nature.com
Neurogenic regions of mammalian brain produce many more neurons that will eventually
survive and reach a mature stage. Developmental cell death affects both embryonically …

[HTML][HTML] Multifunctional regulatory protein connective tissue growth factor (CTGF): A potential therapeutic target for diverse diseases

M Fu, D Peng, T Lan, Y Wei, X Wei - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Connective tissue growth factor (CTGF), a multifunctional protein of the CCN family,
regulates cell proliferation, differentiation, adhesion, and a variety of other biological …

The role of astrocytes in the generation, migration, and integration of new neurons in the adult olfactory bulb

A Gengatharan, RR Bammann… - Frontiers in …, 2016 - frontiersin.org
In mammals, new neurons in the adult olfactory bulb originate from a pool of neural stem
cells in the subventricular zone of the lateral ventricles. Adult-born cells play an important …

Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

NA Vasistha, M Pardo-Navarro, J Gasthaus… - Molecular …, 2020 - nature.com
Severe infections during pregnancy are one of the major risk factors for cognitive impairment
in the offspring. It has been suggested that maternal inflammation leads to dysfunction of …

Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties

P Farrow, K Khodosevich, Y Sapir, A Schulmann… - Elife, 2015 - elifesciences.org
AMPA receptor (AMPAR) function is modulated by auxiliary subunits. Here, we report on
three AMPAR interacting proteins—namely CKAMP39, CKAMP52 and CKAMP59—that …