Cognitive reserve in model systems for mechanistic discovery: The importance of longitudinal studies
The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …
models, directed at understanding and modifying the relationship between cognition and …
Comparative neuropathology in aging primates: A perspective
C Freire‐Cobo, MK Edler, M Varghese… - American journal of …, 2021 - Wiley Online Library
While humans exhibit a significant degree of neuropathological changes associated with
deficits in cognitive and memory functions during aging, non‐human primates (NHP) present …
deficits in cognitive and memory functions during aging, non‐human primates (NHP) present …
Immune proteins C1q and CD47 may contribute to aberrant microglia-mediated synapse loss in the aging monkey brain that is associated with cognitive impairment
Cognitive impairment in learning, memory, and executive function occurs in normal aging
even in the absence of Alzheimer's disease (AD). While neurons do not degenerate in …
even in the absence of Alzheimer's disease (AD). While neurons do not degenerate in …
Neuronal properties of pyramidal cells in lateral prefrontal cortex of the aging rhesus monkey brain are associated with performance deficits on spatial working …
Age-related declines in cognitive abilities occur as early as middle-age in humans and
rhesus monkeys. Specifically, performance by aged individuals on tasks of executive …
rhesus monkeys. Specifically, performance by aged individuals on tasks of executive …
Myelin dystrophy impairs signal transmission and working memory in a multiscale model of the aging prefrontal cortex
Normal aging leads to myelin alterations in the rhesus monkey dorsolateral prefrontal cortex
(dlPFC), which are positively correlated with degree of cognitive impairment. It is …
(dlPFC), which are positively correlated with degree of cognitive impairment. It is …
Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially …
Abstract Layer 3 (L3) pyramidal neurons in aged rhesus monkey lateral prefrontal cortex
(LPFC) exhibit significantly elevated excitability in vitro and reduced spine density compared …
(LPFC) exhibit significantly elevated excitability in vitro and reduced spine density compared …
[HTML][HTML] Myelin dystrophy in the aging prefrontal cortex leads to impaired signal transmission and working memory decline: a multiscale computational study
Normal aging leads to myelin alternations in the rhesus monkey dorsolateral prefrontal
cortex (dlPFC), which are often correlated with cognitive impairment. It is hypothesized that …
cortex (dlPFC), which are often correlated with cognitive impairment. It is hypothesized that …
Localization and characterization of myelin damage in behaviorally characterized normal aging and calorie restricted rhesus macaques using quantitative …
HI Haque - 2023 - open.bu.edu
The normal aging process in humans is characterized by a number of hallmark changes
including decreased white matter volume in the brain and accompanying cognitive decline …
including decreased white matter volume in the brain and accompanying cognitive decline …
Layer 3 pyramidal neurons of rhesus monkeys in aging and after ischemic injury
WWE Chang - 2022 - search.proquest.com
Abstract Layer 3 (L3) pyramidal neurons are involved in intrinsic and extrinsic corticocortical
communications that are integral to area specific cortical functions. The functional and …
communications that are integral to area specific cortical functions. The functional and …
Distribution of Astrocytes in the Prefrontal and Visual Cortices of the Middle-Aged Rhesus Monkey
PBC Mendoza - 2022 - search.proquest.com
Neuroscience research has been largely focused on neurons, while an equally important
cell type, glia, was sidelined until recently. Astrocytes are star-shaped glial cells responsible …
cell type, glia, was sidelined until recently. Astrocytes are star-shaped glial cells responsible …