Before the first description of hay fever in 1870, there was very little awareness of allergic
disease, which is actually similar to the situation in prehygiene villages in Africa today. The …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgE‐mediated allergies has …

The availability of allergen molecules ('components') from several protein families has
advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled …

This parameter was developed by the Joint Task Force on Practice Parameters,
representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the …

This is the fourth iteration of this parameter entitled “The Diagnosis and Management of
Anaphylaxis.” The first anaphylaxis parameter was published in 1998 and the last in 2010 …

Understanding the impact of glycosylation and keeping a close control on glycosylation of
product candidates are required for both novel and biosimilar monoclonal antibodies (mAbs) …

Background Immune checkpoint inhibitors are poised to revolutionize the management of a
growing number of malignancies. Unfortunately, the management of steroid-refractory …

In recent decades, tickborne disease (TBD) cases and established populations of medically
important ticks have been reported over expanding geographic areas, and an increasing …

Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal, and
therefore establishing its cause is pivotal to long-term risk management. Our recent work has …