Ionic liquids are remarkable chemical compounds, which find applications in many areas of
modern science. Because of their highly tunable nature and exceptional properties, ionic …

The ability to efficiently access cytosolic proteins is desired in both biological research and
medicine. However, targeting intracellular proteins is often challenging, because to reach …

Oral drug administration is the preferred method for delivering medications due to its safety,
ease of ingestion, high patient compliance, absence of pain, and adaptability to a wide …

Bile acids are synthesized in the liver, stored in the gallbladder, and secreted into the
duodenum at meals. Apical sodium-dependent bile acid transporter (ASBT), an ileal Na+ …

Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …

Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a
parent drug in the body. In the past, prodrugs were used as a last option; however …

Bacterial resistance to present antibiotics is emerging at a high pace that makes the
development of new treatments a must. At the same time, the development of novel …

Abstract Covalent Organic Frameworks (COFs) are a remarkable class of porous solids and
they are defined as organic polymeric materials having a large surface area and chemical …

Challenges to effective delivery of drugs following oral administration has attracted growing
interest over recent decades. Small molecule drugs (< 1000 Da) are generally absorbed …

This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …