Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal
and molecular processes. Technological innovations now allow for parallel investigation of …

The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …

The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

INTRODUCTION The brain of mammals consists of an enormously dense network of
neuronal wires: the axons and dendrites of nerve cells. Their packing density is so high that …

The fluorescent glutamate indicator iGluSnFR enables imaging of neurotransmission with
genetic and molecular specificity. However, existing iGluSnFR variants exhibit low in vivo …

Since the brain was found to be somehow flexible, plastic, researchers worldwide have
been trying to comprehend its fundamentals to better understand the brain itself, make …

With the rapid evolution in the automation of serial electron microscopy in life sciences, the
acquisition of terabyte-sized datasets is becoming increasingly common. High resolution …

The neotenous, or delayed, development of primate neurons, particularly human ones, is
thought to underlie primate-specific abilities like cognition. We tested whether synaptic …

Long-term memory formation (LTM) is a process accompanied by energy-demanding
structural changes at synapses and increased spine density. Concomitant increases in both …