The problems with anticancer therapy are resistance and toxicity. From 3000 Cisplatin
derivatives tested as antitumor agents, most of them have been rejected, due to toxicity. The …

Adjuvant, as an important part of vaccines, can observably enhance the magnitude, breadth
and durability of immune responses. Nanoadjuvants, as novel vaccine adjuvants, have …

Background: Immune checkpoint inhibitors (ICIs) have shown efficacy in patients with
metastatic urothelial cancer (mUC), however, only a small subset of patients could benefit …

Colorectal cancer (CRC) is the third most common malignant tumor and the second most
fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer …

Background: Previous studies revealed that colonic cancer-associated fibroblasts (CAFs)
are associated with the modulation of the colon tumor microenvironment (TME). However …

Simple Summary Leptomeningeal disease in melanoma (LMM) patients is characterized by
aggressiveness and dismal outcomes. Clinical studies and case reports demonstrate the …

Resistance to neoadjuvant chemoradiation therapy (neo-CRT) is a significant clinical
problem in the treatment of locally advanced rectal cancer. Identification of novel therapeutic …

Cancer is the leading cause of death globally and there is a worldwide cancer epidemic.
Immunotherapy has emerged as a promising anticancer therapy. In particular, oncolytic …

Purpose While leptomeningeal metastasis (LM) from estrogen receptor-positive, HER2-
negative advanced breast cancer (ER+ HER2-ABC) has a poor prognosis, the details of …

Radiation therapy remains an important component of cancer treatment. Gene-encoded
proteins were the actual executors of cellular functions. Proteomic was a novel technology …