Experimental design methodology (DOE) surpasses traditional (one variable at a time)
approach in improving the chromatographic separation performance with minimum effort …

Drug repositioning is a revolution breakthrough of drug discovery that presents outstanding
privilege with already safer agents by scanning the existing candidates as therapeutic …

Salting-out induced liquid–liquid microextraction method has been developed for plasma
sample treatment before determination of alogliptin by high performance liquid …

Abstract Pioglitazone is a Peroxisome Proliferator-Activated Receptor (PPAR) agonist of the
thiazolidinedione class of compounds with promising anticancer activity. An innovative …

This article discusses various analytical techniques for quantifying alogliptin benzoate in
pharmaceutical dosage forms and biological fluids. Alogliptin is considered one of the recent …

The instrumental analytical methods that have been developed and utilized for the
determination of thiazolidinedione in bulk medications, formulations and biological fluids …

Failure to attain and sustain long term glycemic control is an ongoing challenge in diabetes
therapy. The trend to use a combined therapy and the risk of drug-drug interaction (DDI) are …

Renal impairment can affect the elimination of hepatically metabolized drugs. Bexarotene
(BXT) used for cutaneous T‐cell lymphoma is highly bound in plasma and metabolized by …

A novel, high throughput and sensitive LC-MS/MS assay method was developed and fully
validated for quantitative determination of pioglitazone, its hydroxyl metabolite and alogliptin …

A highly effective high‐performance thin‐layer chromatographic methodology has been
developed and validated for the concurrent measurement of teneligliptin hydrobromide …