Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

Mild cognitive impairment (MCI) represents a transitional stage between healthy aging and
dementia, and affects 10–15% of the population over the age of 65. The failure of drug trials …

Purpose To provide an overview on positron emission tomography (PET) imaging of tau
pathology in Alzheimer's disease (AD) and other neurodegenerative disorders. Results …

Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Ironically, population aging which is considered a public health success has been
accompanied by a myriad of new health challenges, which include neurodegenerative …

Hyperphosphorylated tau aggregates, also known as neurofibrillary tangles, are a hallmark
neuropathological feature of Alzheimer's disease (AD). Molecular imaging of tau by positron …

Although the diagnosis of dementia is still largely a clinical one, based on history and
disease course, neuroimaging has dramatically increased our ability to accurately diagnose …

Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by four-
repeat tau deposition in various cell types and anatomical regions, and can manifest as …

Introduction The molecular mechanism of neurodegeneration, including tau and neurite
complexity, is an important topic in Alzheimer's disease (AD) research. Methods We …

White matter hyperintensities are a marker of small vessel cerebrovascular disease that are
strongly related to cognition in older adults. Similarly, medial temporal lobe atrophy is well …