In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying
mechanisms, and whether dysfunction occurs uniformly among cells, remain unclear. We …

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity
in Cystic Fibrosis | Journal of Innate Immunity | Karger Publishers Skip to Main Content S …

Introduction: Centipedes are one of the oldest and most successful lineages of venomous
terrestrial predators. Despite their use for centuries in traditional medicine, centipede …

Disruption and dysregulation of cellular calcium channel function can lead to diseases such
as ischemic stroke, heart failure, and arrhythmias. Corresponding calcium channel drugs …

A long-held tenet of neuromuscular transmission is that calcium-dependent neurotransmitter
release is mediated by N-type calcium channels in frog but P/Q-type channels in mammals …

Botulinum neurotoxins (BoNTs) are endopeptidases that target motor neurons and block
acetylcholine neurotransmitter release. This action results in the muscle paralysis that …

Besides antitumor therapy for patients with the paraneoplastic form of Lambert–Eaton
myasthenic syndrome (LEMS), the mainstay of symptomatic treatment in LEMS is 3, 4 …

GV-58 ((2 R)-2-[(6-{[(5-methylthiophen-2-yl) methyl] amino}-9-propyl-9H-purin-2-yl) amino]
butan-1-ol) is recognized to be an activator of N-and P/Q-type Ca2+ currents. However, its …

The Na+ leak‐current channel (NALCN) regulates locomotion, respiration, and intellectual
development. Previous work highlighted striking similarities between characteristic …

Roscovitine is an antitumor purine inhibitor of cyclin-dependent kinase CDK5, for which it
displays submicromolar affinity. It reached phase IIb clinical trials in 2007. The search for …