Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …

Human aldo-keto reductases (AKRs) catalyze the NADPH-dependent reduction of carbonyl
groups to alcohols for conjugation reactions to proceed. They are implicated in resistance to …

The generation of reactive oxygen species (ROS) and an altered redox status are common
biochemical aspects in cancer cells. ROS can react with the polyunsaturated fatty acids of …

The aldo-keto reductase (AKR) protein superfamily contains> 190 members that fall into 16
families and are found in all phyla. These enzymes reduce carbonyl substrates such as …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors that are involved in regulating glucose and lipid homeostasis, inflammation …

Oxidative stress is a silent participant in all chronic progressive pathology and degenerative
disorders. Neurodegeneration and cognitive impairment are caused by increased …

Introduction Cellular metabolism is altered during cancer initiation and progression, which
allows cancer cells to increase anabolic synthesis, avoid apoptosis and adapt to low nutrient …

There is considerable interest in the development of an inhibitor of aldo–keto reductase
(AKR) 1C3 (type 5 17β-hydroxysteroid dehydrogenase and prostaglandin F synthase) as a …

Cancer formation is a highly regulated and complex process, largely dependent on its
microenvironment. This complexity highlights the need for developing novel target-based …

Abstract Aldo-Keto-Reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase
(HSD)/prostaglandin (PG) F 2α synthase) is the only 17β-HSD that is not a short-chain …