The human genome project.
MV Olson - Proceedings of the National Academy of …, 1993 - National Acad Sciences
The Human Genome Project in the United States is now well underway. Its programmatic
direction was largely set by a National Research Council report issued in 1988. The broad …
direction was largely set by a National Research Council report issued in 1988. The broad …
Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome
G Pilia, RM Hughes-Benzie, A MacKenzie… - Nature …, 1996 - nature.com
Abstract Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked condition characterized
by pre-and postnatal overgrowth with visceral and skeletal anomalies. To identify the …
by pre-and postnatal overgrowth with visceral and skeletal anomalies. To identify the …
The human Y chromosome: overlapping DNA clones spanning the euchromatic region
S Foote, D Vollrath, A Hilton, DC Page - Science, 1992 - science.org
The human Y chromosome was physically mapped by assembling 196 recombinant DNA
clones, each containing a segment of the chromosome, into a single overlapping array. This …
clones, each containing a segment of the chromosome, into a single overlapping array. This …
Four strikes against physical mapping of DNA
Physical mapping is a central problem in molecular biology and the human genome project.
The problem is to reconstruct the relative position of fragments of DNA along the genome …
The problem is to reconstruct the relative position of fragments of DNA along the genome …
Physical and genetic mapping of the human X chromosome centromere: repression of recombination
MM Mahtani, HF Willard - Genome research, 1998 - genome.cshlp.org
Classical genetic studies in Drosophila and yeast have shown that chromosome
centromeres have a cis-acting ability to repress meiotic exchange in adjacent DNA. To …
centromeres have a cis-acting ability to repress meiotic exchange in adjacent DNA. To …
Genome analysis and the human X chromosome
A unified genetic, physical, and functional map of the human X chromosome is being built
through a concerted, international effort. About 40 percent of the 160 million base pairs of …
through a concerted, international effort. About 40 percent of the 160 million base pairs of …
A comprehensive genetic linkage map of the human genome
NIH/CEPH Collaborative Mapping Group - Science, 1992 - science.org
Table 1. Characteristics of the genetic markers. Polymorphic allele systems for each
chromosome are listed by locus in alphabetical order, unless no locus name has been …
chromosome are listed by locus in alphabetical order, unless no locus name has been …
Mapping human chromosomes by walking with sequence-tagged sites from end fragments of yeast artificial chromosome inserts
J Kere, R Nagaraja, S Mumm, A Ciccodicola, M D'Urso… - Genomics, 1992 - Elsevier
Sequence-tagged sites (STSs) derived from end fragments of chromosome-specific yeast
artificial chromosomes (YACs) can facilitate the assembly of an overlapping YAC/STS map …
artificial chromosomes (YACs) can facilitate the assembly of an overlapping YAC/STS map …
A 1.6-Mb contig of yeast artificial chromosomes around the human factor VIII gene reveals three regions homologous to probes for the DXS115 locus and two for the …
D Freije, D Schlessinger - American journal of human genetics, 1992 - ncbi.nlm.nih.gov
Two yeast artificial chromosome (YAC) libraries were screened for probes in Xq28, around
the gene for coagulation factor VIII (F8). A set of 30 YACs were recovered and assembled …
the gene for coagulation factor VIII (F8). A set of 30 YACs were recovered and assembled …
X-ray-induced mutations in mouse embryonic stem cells
JW Thomas, C LaMantia… - Proceedings of the …, 1998 - National Acad Sciences
Deletion complexes consisting of multiple chromosomal deletions induced at single loci can
provide a means for functional analysis of regions spanning several centimorgans in model …
provide a means for functional analysis of regions spanning several centimorgans in model …