Random fluctuations (noise) in gene expression can be studied from two complementary
perspectives: following expression in a single cell over time or comparing expression …

Bacterial cell persistence, crucial for survival under adverse conditions like antibiotic
exposure, is intrinsically linked to stochastic fluctuations in gene expression. Certain genes …

Negative feedback regulation is a well-known motif for suppressing deleterious fluctuations
in gene product levels. We systematically compare two scenarios where negative feedback …

The timing of biochemical processes within cells is inextricably linked to the level of key
regulatory proteins crossing critical threshold levels. Recent research has primarily focused …

Bacterial cell persistence, crucial for survival under adverse conditions like antibiotic
exposure, is intrinsically linked to stochastic fluctuations in gene expression. Certain genes …

Numerous biological timing mechanisms are associated with the duration required for key
regulatory molecules to reach critical threshold levels. Recent studies have mainly explored …

We consider a protein that negatively regulates the rate with which a cell grows. Since less
growth means less protein dilution, this mechanism forms a positive feedback loop on the …

Regulation of gene expression is represented by a variety of control motifs, mathematical
models of which can provide a theoretical estimate of the process parameters. In this project …