Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …

Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune
responses according to peripheral cues. After four decades of research, we now know that …

Immune tolerance is necessary to prevent the immune system from reacting against self, and
thus to avoid the development of autoimmune diseases. In this review, we discuss key …

Invariant natural killer T cells (i NKT cells) can produce copious amounts of interleukin 4 (IL-
4) early during infection. However, indirect evidence suggests they may produce this …

Somatic recombination of TCR genes in immature thymocytes results in some cells with
useful TCR specificities, but also many with useless or potentially self-reactive specificities …

Dendritic cells (DC) are professional antigen presenting cells comprising a variety of
subsets, as either resident or migrating cells, in lymphoid and non-lymphoid organs. In the …

It is assumed that anti-CTLA-4 antibodies cause tumor rejection by blocking negative
signaling from B7-CTLA-4 interactions. Surprisingly, at concentrations considerably higher …

Dendritic cells (DCs) are a heterogeneous population playing a pivotal role in immune
responses and tolerance. DCs promote immune tolerance by participating in the negative …

Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses.
Accordingly, recent evidence from clinical studies and experimental models implicates DCs …