Bumetanide (BTN or BUM) is a FDA-approved potent loop diuretic (LD) that acts by antagonizing sodium-potassium-chloride (Na-K-Cl) cotransporters, NKCC1 (SLc12a2) and …
HC So, CKL Chau, WT Chiu, KS Ho, CP Lo… - Nature …, 2017 - nature.com
Abstract Knowledge of psychiatric disease genetics has advanced rapidly during the past decade with the advent of genome-wide association studies (GWAS). However, less …
Aberrant expression ratio of Cl− transporters, NKCC1 and KCC2, is implicated in several brain conditions. NKCC1 inhibition by the FDA-approved diuretic drug, bumetanide, rescues …
B Boyarko, S Podvin, B Greenberg… - Frontiers in …, 2023 - frontiersin.org
Therapeutics discovery and development for Alzheimer's disease (AD) has been an area of intense research to alleviate memory loss and the underlying pathogenic processes. Recent …
P Lam, J Newland, RLM Faull, A Kwakowsky - Molecules, 2023 - mdpi.com
Neurological diseases including Alzheimer's, Huntington's disease, Parkinson's disease, Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are …
AR Murillo-de-Ozores, M Chávez-Canales… - Frontiers in …, 2020 - frontiersin.org
The role of Cl–as an intracellular signaling ion has been increasingly recognized in recent years. One of the currently best described roles of Cl–in signaling is the modulation of the W …
Cognitive impairment in schizophrenia (CIAS) is the most critical predictor of functional outcome. Limited understanding of the cellular mechanisms of CIAS hampers development …
KR Vogel, GR Ainslie, DC Walters, A McConnell… - Journal of inherited …, 2018 - Springer
We present an update to the status of research on succinic semialdehyde dehydrogenase (SSADH) deficiency (SSADHD), a rare disorder of GABA metabolism. This is an unusual …
J Poblano, I Castillo‐Tobías, L Berlanga… - Basic & Clinical …, 2024 - Wiley Online Library
Alzheimer's disease is characterized by progressive cognitive decline, and behavioural and psychological symptoms of dementia are common. The APOE ε4 allele, a genetic risk factor …