Assuring a healthy proteome is indispensable for survival and organismal health. Proteome
disbalance and the loss of the proteostasis buffer are hallmarks of various diseases. The …

The molecular chaperone Hsp90 is one component of a highly complex and interactive
cellular proteostasis network (PN) that participates in protein folding, directs misfolded and …

Molecular chaperones have recently emerged as fundamental regulators of salient
biological routines, including metabolic adaptations to environmental changes. Yet, many of …

Abstract Heat shock protein 90 (Hsp90) is a molecular chaperone that facilitates the
maturation of its client proteins including protein kinases, transcription factors, and steroid …

Abstract Heat shock protein 90 (Hsp90) is an ATP dependent molecular chaperone deeply
involved in the complex network of cellular signaling governing some key functions, such as …

Herein, we describe the synthesis and structure–activity relationships of cyclic peptides
designed to target heat shock protein 90 (Hsp90). Generating 19 compounds and evaluating …

Background: Cisplatin (CDDP), a small molecule platinum-based compound, is an effective
anticancer drug used against a wide range of human neoplasms. Long-term clinical use of …

Protein-protein interactions (PPIs) form complex cellular networks fundamental to many key
biological processes, including signal transduction, cell proliferation and DNA repair. In …

Although hepatocellular carcinoma (HCC)-related mortality has increased over the past
decades, treatment options are still very limited, underlining the need for developing new …

Hereditary demyelinating neuropathies linked to peripheral myelin protein 22 (PMP22)
involve the disruption of normal protein trafficking and are therefore relevant targets for …