Extracellular adenine nucleotides play important roles in cell–cell communication and tissue
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …

Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

ATP, NAD+, and nucleic acids are abundant purines that, in addition to having critical
intracellular functions, have evolved extracellular roles as danger signals released in …

The plasma membrane adenosine triphosphate (ATP) release channel pannexin 1 (PANX1)
has been implicated in many physiological and pathophysiological processes associated …

Diabetic cardiomyopathy (DCM), as a common complication of diabetes, is characterized by
chronic low-grade inflammation. The NLRP3 inflammasome is a key sensor mediating …

In recent years, a substantial body of evidence has emerged demonstrating that purine and
pyrimidine synthesis and metabolism play major roles in controlling embryonic and fetal …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that
hydrolyse extracellular purine and pyrimidine nucleotides, eg, ATP, UTP, ADP, UDP, AMP …