Artificial intelligence to deep learning: machine intelligence approach for drug discovery

R Gupta, D Srivastava, M Sahu, S Tiwari, RK Ambasta… - Molecular …, 2021 - Springer
Drug designing and development is an important area of research for pharmaceutical
companies and chemical scientists. However, low efficacy, off-target delivery, time …

A review of computational drug repositioning: strategies, approaches, opportunities, challenges, and directions

TN Jarada, JG Rokne, R Alhajj - Journal of cheminformatics, 2020 - Springer
Drug repositioning is the process of identifying novel therapeutic potentials for existing drugs
and discovering therapies for untreated diseases. Drug repositioning, therefore, plays an …

[HTML][HTML] Review of drug repositioning approaches and resources

H Xue, J Li, H Xie, Y Wang - International journal of biological …, 2018 - ncbi.nlm.nih.gov
Drug discovery is a time-consuming, high-investment, and high-risk process in traditional
drug development. Drug repositioning has become a popular strategy in recent years …

A survey of current trends in computational drug repositioning

J Li, S Zheng, B Chen, AJ Butte… - Briefings in …, 2016 - academic.oup.com
Computational drug repositioning or repurposing is a promising and efficient tool for
discovering new uses from existing drugs and holds the great potential for precision …

A review of computational drug repurposing

K Park - Translational and clinical pharmacology, 2019 - synapse.koreamed.org
Although sciences and technology have progressed rapidly, de novo drug development has
been a costly and time-consuming process over the past decades. In view of these …

DDR: efficient computational method to predict drug–target interactions using graph mining and machine learning approaches

RS Olayan, H Ashoor, VB Bajic - Bioinformatics, 2018 - academic.oup.com
Motivation Finding computationally drug–target interactions (DTIs) is a convenient strategy
to identify new DTIs at low cost with reasonable accuracy. However, the current DTI …

Plant Derived Bioactive Compounds, Their Anti-Cancer Effects and In Silico Approaches as an Alternative Target Treatment Strategy for Breast Cancer: An Updated …

V Shrihastini, P Muthuramalingam, S Adarshan… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer is one of the leading causes of death among women
worldwide. Breast cancer may be provoked due to several physical, chemical and …

Use of big data in drug development for precision medicine: an update

T Qian, S Zhu, Y Hoshida - … review of precision medicine and drug …, 2019 - Taylor & Francis
Introduction: Big-data-driven drug development resources and methodologies have been
evolving with ever-expanding data from large-scale biological experiments, clinical trials …

Self-management interventions for chronic kidney disease: a systematic review and meta-analysis

S Peng, J He, J Huang, L Lun, J Zeng, S Zeng, L Zhang… - BMC nephrology, 2019 - Springer
Background Self-management intervention aims to facilitate an individual's ability to make
lifestyle changes. The effectiveness of this intervention in non-dialysis patients with chronic …

Computational and experimental advances in drug repositioning for accelerated therapeutic stratification

K Shameer, B Readhead… - Current topics in medicinal …, 2015 - ingentaconnect.com
Drug repositioning is an important component of therapeutic stratification in the precision
medicine paradigm. Molecular profiling and more sophisticated analysis of longitudinal …