Dynamic gain and loss of synapses is fundamental to healthy brain function. While
Alzheimer's Disease (AD) treatment strategies have largely focussed on beta-amyloid and …

The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Hypersynchronization has been proposed as a synaptic dysfunction biomarker in the
Alzheimer's disease continuum, reflecting the alteration of the excitation/inhibition balance …

Individuals diagnosed with mild cognitive impairment (MCI) are at high risk of transition to
Alzheimer's disease (AD). However, little is known about functional characteristics of the …

Objective The purpose of this study is to characterize functional connectivity changes in mild
cognitive impaired Alzheimer's disease (MCI-AD) under resting and cognitive task …

Background: Temporo-parietal and medial temporal cortex atrophy are associated with mild
cognitive impairment (MCI) due to Alzheimer disease (AD) as well as the reduction of …

Subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are early stages of
Alzheimer's disease (AD). Neurophysiological markers such as electroencephalography …

Background Dementia is caused by a variety of neurodegenerative diseases and is
associated with a decline in memory and other cognitive abilities, while inflicting an …

Work from the past 40 years has unraveled a wealth of information on the cellular and
molecular mechanisms underlying synaptic plasticity and their relevance in physiological …

Accurately recognising patients with progressive mild cognitive impairment (pMCI) who will
develop Alzheimer's disease (AD) in subsequent years is very important, as early …