Antimicrobial peptides as therapeutic agents: Opportunities and challenges
M Mahlapuu, C Björn, J Ekblom - Critical reviews in biotechnology, 2020 - Taylor & Francis
The rapid development of microbial resistance to conventional antibiotics has accelerated
efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial …
efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial …
[HTML][HTML] Antimicrobial peptides: an emerging category of therapeutic agents
Antimicrobial peptides (AMPs), also known as host defense peptides, are short and
generally positively charged peptides found in a wide variety of life forms from …
generally positively charged peptides found in a wide variety of life forms from …
[HTML][HTML] Reassessing the host defense peptide landscape
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
The Innate Immune Response to Mycobacterium tuberculosis Infection
MM Ravesloot-Chávez, E Van Dis… - Annual review of …, 2021 - annualreviews.org
Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …
An overview of antimicrobial peptides and the latest advances in their development
Introduction: The recent dramatic increase in the incidence of antimicrobial resistance has
been recognized by organizations such as the United Nations and World Health …
been recognized by organizations such as the United Nations and World Health …
[HTML][HTML] The human cathelicidin LL-37—A pore-forming antibacterial peptide and host-cell modulator
The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of
peptides in host defence. It has a remarkably wide functional repertoire that includes direct …
peptides in host defence. It has a remarkably wide functional repertoire that includes direct …
Vitamin D and respiratory tract infections: a systematic review and meta-analysis of randomized controlled trials
P Bergman, ÅU Lindh, L Björkhem-Bergman, JD Lindh - PloS one, 2013 - journals.plos.org
Background Low levels of 25-OH vitamin D are associated with respiratory tract infection
(RTI). However, results from randomized controlled trials are inconclusive. Therefore, we …
(RTI). However, results from randomized controlled trials are inconclusive. Therefore, we …
[HTML][HTML] Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense
Lung epithelial cells are increasingly recognized to be active effectors of microbial defense,
contributing to both innate and adaptive immune function in the lower respiratory tract. As …
contributing to both innate and adaptive immune function in the lower respiratory tract. As …
[HTML][HTML] Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era
L Lin, J Chi, Y Yan, R Luo, X Feng, Y Zheng… - … Pharmaceutica Sinica B, 2021 - Elsevier
Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or
anticarcinogens that present a general killing mechanism through the physical disruption of …
anticarcinogens that present a general killing mechanism through the physical disruption of …
Machine learning prediction of antimicrobial peptides
Antibiotic resistance constitutes a global threat and could lead to a future pandemic. One
strategy is to develop a new generation of antimicrobials. Naturally occurring antimicrobial …
strategy is to develop a new generation of antimicrobials. Naturally occurring antimicrobial …