▪ Abstract Many neurons in the mammalian central nervous system communicate through
electrical synapses, defined here as gap junction–mediated connections. Electrical …

Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

Taking a step-by-step approach to modelling neurons and neural circuitry, this textbook
teaches students how to use computational techniques to understand the nervous system at …

Synapses show widely varying degrees of short-term facilitation and depression. Several
mechanisms have been proposed to underlie short-term plasticity, but the contributions of …

Thalamocortical (TC) synapses carry information into the neocortex, but they are far
outnumbered by excitatory intracortical (IC) synapses. We measured the synaptic properties …

Presynaptic short-term plasticity is an important adaptive mechanism regulating synaptic
transmitter release at varying action potential frequencies. However, the underlying …

The terms 'wiring'and 'volume'transmission (WT and VT) have been introduced to provide a
systematic categorization of intercellular communication in the brain. WT is one-to-one …

The calyx of Held is a large glutamatergic synapse in the mammalian auditory brainstem. By
using brain slice preparations, direct patch-clamp recordings can be made from the nerve …

We have studied the origin of quantal variability for small synaptic vesicles (SSVs) and large
dense-cored vesicles (LDCVs). As a model, we used serotonergic Retzius neurons of leech …

Diffusion of glutamate from the synaptic cleft can activate high-affinity receptors, but is not
thought to contribute to fast AMPA receptor-mediated transmission. Here, we show that …