Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …

Valvular heart disease (VHD) is the next epidemic in the cardiovascular field, affecting
millions of people worldwide and having a major impact on health care systems. With aging …

Background: Calcific aortic stenosis (CAS) is the most common valvular heart disease in
older adults and has no effective preventive therapies. Genome-wide association studies …

Calcific aortic valve disease (CAVD) is a common acquired valvulopathy, which carries a
high burden of mortality. Chronic inflammation has been postulated as the predominant …

Calcific aortic valve disease is a prevalent cardiovascular disease with no available drugs
capable of effectively preventing its progression. Hence, an efficient drug delivery system …

Despite numerous promising therapeutic targets, there are no proven medical treatments for
calcific aortic stenosis (AS). Multiple stakeholders need to come together and several …

In calcific aortic valve disease (CAVD), mechanosensitive valvular cells respond to fibrosis-
and calcification-induced tissue stiffening, further driving pathophysiology. No …

Aims To assess the trends in calcific aortic valve disease (CAVD) epidemiology, with an
emphasis on CAVD mortality, leading risk factors, and their associations with age, period …

Multiomics is a powerful technique in molecular biology that facilitates the identification of
new associations among different molecules (genes, proteins & metabolites). It has attracted …

Single-cell RNA-seq (scRNA-seq) is a powerful genomics technology to interrogate the
cellular composition and behaviors of complex systems. While the number of scRNA-seq …