Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

GSDM family is a group of critical proteins that mediate pyroptosis and plays an important
role in cell death and inflammation. However, their specific function in clear cell renal cell …

The epidemic of cardiovascular diseases (CVDs) is predicted to spread rapidly in advanced
countries accompanied by the high prevalence of risk factors. In terms of pathogenesis, the …

The primary underlying contributor for cataract, a leading cause of vision impairment and
blindness worldwide, is oxidative stress. Oxidative stress triggers protein damage, cell …

Significant interindividual and intraindividual variations on cytochrome P450 (CYP)-
mediated drug metabolism exist in the general population globally. Genetic polymorphisms …

The AlkB family consists of Fe (II)-and α-ketoglutarate-dependent dioxygenases that can
catalyze demethylation on a variety of substrates, such as RNA and DNA, subsequently …

Excessive drinking damages the central nervous system of individuals and can even cause
alcohol use disorder (AUD). AUD is regulated by both genetic and environmental factors …

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, classically
associated with the regulation of xenobiotic metabolism in response to environmental toxins …

Aging is a necessary process of life associated with various mechanisms, such as genomic
instability, loss of proteostasis, deregulated nutrient sensing, and cellular senescence …