Mechanistic understanding the bioeffects of ultrasound-driven microbubbles to enhance macromolecule delivery

P Qin, T Han, CH Alfred, L Xu - Journal of controlled release, 2018 - Elsevier
Ultrasound-driven microbubbles can trigger reversible membrane perforation
(sonoporation), open interendothelial junctions and stimulate endocytosis, thereby providing …

Sonoporation: mechanistic insights and ongoing challenges for gene transfer

A Delalande, S Kotopoulis, M Postema, P Midoux… - Gene, 2013 - Elsevier
Microbubbles first developed as ultrasound contrast agents have been used to assist
ultrasound for cellular drug and gene delivery. Their oscillation behavior during ultrasound …

[HTML][HTML] A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer

G Dimcevski, S Kotopoulis, T Bjånes, D Hoem… - Journal of Controlled …, 2016 - Elsevier
Background The primary aim of our study was to evaluate the safety and potential toxicity of
gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer …

Ultrasound and microbubble mediated drug delivery: acoustic pressure as determinant for uptake via membrane pores or endocytosis

I De Cock, E Zagato, K Braeckmans, Y Luan… - Journal of controlled …, 2015 - Elsevier
Although promising results are achieved in ultrasound mediated drug delivery, its underlying
biophysical mechanisms remain to be elucidated. Pore formation as well as endocytosis has …

Ultrasound microrobots with reinforcement learning

M Schrage, M Medany, D Ahmed - Advanced Materials …, 2023 - Wiley Online Library
Ultrasound is an attractive modality for controlling micro/nanorobots due to penetrating deep
into tissue, not being affected by the opaque nature of animal bodies, and generating a …

[HTML][HTML] Contrast-enhanced and targeted ultrasound

M Postema, OH Gilja - World journal of gastroenterology: WJG, 2011 - ncbi.nlm.nih.gov
Ultrasonic imaging is becoming the most popular medical imaging modality, owing to the
low price per examination and its safety. However, blood is a poor scatterer of ultrasound …

The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication

A Jangjou, AH Meisami, K Jamali, MH Niakan… - Journal of Biomedical …, 2021 - Springer
Abstract Microbubbles are typically 0.5–10 μm in size. Their size tends to make it easier for
medication delivery mechanisms to navigate the body by allowing them to be swallowed …

Sonoporation using nanoparticle-loaded microbubbles increases cellular uptake of nanoparticles compared to co-incubation of nanoparticles and microbubbles

S Snipstad, S Hanstad, A Bjørkøy, Ý Mørch… - Pharmaceutics, 2021 - mdpi.com
Therapeutic agents can benefit from encapsulation in nanoparticles, due to improved
pharmacokinetics and biodistribution, protection from degradation, increased cellular uptake …

Biological active matter aggregates: Inspiration for smart colloidal materials

FJ Vernerey, E Benet, L Blue, AK Fajrial… - Advances in colloid and …, 2019 - Elsevier
Aggregations of social organisms exhibit a remarkable range of properties and
functionalities. Multiple examples, such as fire ants or slime mold, show how a population of …

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

T van Rooij, V Daeichin, I Skachkov… - International journal …, 2015 - Taylor & Francis
Ultrasound contrast agents (UCAs) are used routinely in the clinic to enhance contrast in
ultrasonography. More recently, UCAs have been functionalised by conjugating ligands to …