The good, the bad, and the deadly: adenosinergic mechanisms underlying sudden unexpected death in epilepsy

B Purnell, M Murugan, R Jani, D Boison - Frontiers in neuroscience, 2021 - frontiersin.org
Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in
increased adenosine release, thereby constraining excessive excitation. The exceptionally …

Neuroimaging of sudden unexpected death in epilepsy (SUDEP): insights from structural and resting-state functional MRI studies

LA Allen, RM Harper, S Lhatoo, L Lemieux… - Frontiers in …, 2019 - frontiersin.org
The elusive nature of sudden unexpected death in epilepsy (SUDEP) has led to
investigations of mechanisms and identification of biomarkers of this fatal scenario that …

[图书][B] Simpson's forensic medicine

J Payne-James, RM Jones - 2019 - taylorfrancis.com
Prestigious and authoritative, this fully updated fourteenth edition of Simpson's Forensic
Medicine remains a classic; one of the world's leading introductory texts in the field of …

Brainstem network disruption: a pathway to sudden unexplained death in epilepsy?

SG Mueller, M Nei, LM Bateman… - Human brain …, 2018 - Wiley Online Library
Abstract Observations in witnessed Sudden Unexpected Death in Epilepsy (SUDEP)
suggest that a fatal breakdown of the central autonomic control could play a major role in …

The ventrolateral medulla and medullary raphe in sudden unexpected death in epilepsy

S Patodia, A Somani, M O'Hare, R Venkateswaran… - Brain, 2018 - academic.oup.com
Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature death in
patients with epilepsy. One hypothesis proposes that sudden death is mediated by post-ictal …

[HTML][HTML] Failure to breathe persists without air hunger or alarm following amygdala seizures

GIS Harmata, AE Rhone, CK Kovach, S Kumar… - JCI insight, 2023 - ncbi.nlm.nih.gov
Postictal apnea is thought to be a major cause of sudden unexpected death in epilepsy
(SUDEP). However, the mechanisms underlying postictal apnea are unknown. To …

Incidence, recurrence, and risk factors for peri-ictal central apnea and sudden unexpected death in epilepsy

L Vilella, N Lacuey, JP Hampson, MRS Rani… - Frontiers in …, 2019 - frontiersin.org
Introduction: Peri-ictal breathing dysfunction was proposed as a potential mechanism for
SUDEP. We examined the incidence and risk factors for both ictal (ICA) and post-convulsive …

Disordered breathing in a mouse model of Dravet syndrome

FS Kuo, CM Cleary, JJ LoTurco, X Chen, DK Mulkey - Elife, 2019 - elifesciences.org
Dravet syndrome (DS) is a form of epilepsy with a high incidence of sudden unexpected
death in epilepsy (SUDEP). Respiratory failure is a leading cause of SUDEP, and DS …

The effect of seizure spread to the amygdala on respiration and onset of ictal central apnea

WP Nobis, KAG Otárula, JW Templer, EE Gerard… - Journal of …, 2019 - thejns.org
OBJECTIVE Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death
for patients with refractory epilepsy, and there is increasing evidence for a centrally …

Dysfunctional brain networking among autonomic regulatory structures in temporal lobe epilepsy patients at high risk of sudden unexpected death in epilepsy

LA Allen, RM Harper, R Kumar, M Guye… - Frontiers in …, 2017 - frontiersin.org
Background Sudden unexpected death in epilepsy (SUDEP) is common among young
people with epilepsy. Individuals who are at high risk of SUDEP exhibit regional brain …