Understanding pancreas development can provide clues for better treatments of pancreatic
diseases. However, the molecular heterogeneity and developmental trajectory of the early …

Generation of surrogate cells with stable functional identities is crucial for developing cell-
based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes …

Understanding the mechanisms that underlie the generation and regeneration of β cells is
crucial for developing treatments for diabetes. However, traditional research methods, which …

NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic β
cells. Disruption of Neurod1 during pancreatic development causes severe neonatal …

Historic and emerging studies provide evidence for the deterioration of pancreatic α cell
function and identity in diabetes mellitus. Increased access to human tissue and the …

The in vitro differentiation of insulin-producing beta-like cells can model aspects of human
pancreatic development. Here, we generate 95,308 single-cell transcriptomes and …

Insufficient functional β-cell mass causes diabetes; however, an effective cell replacement
therapy for curing diabetes is currently not available. Reprogramming of acinar cells toward …

The pancreatic islet contains multiple hormone+ endocrine lineages (α, β, δ, PP and ε cells),
but the developmental processes that underlie endocrinogenesis are poorly understood …

The significant advances in the differentiation of human pluripotent stem (hPS) cells into
pancreatic endocrine cells, including functional β-cells, have been based on a detailed …

Background Glucose homeostasis is dependent on functional pancreatic α and ß cells. The
mechanisms underlying the generation and maturation of these endocrine cells remain …