Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

Single-photon avalanche diode (SPAD) arrays are solid-state detectors that offer imaging
capabilities at the level of individual photons, with unparalleled photon counting and time …

Temperature (T) is probably the most fundamental parameter in all kinds of science.
Respective sensors are widely used in daily life. Besides conventional thermometers, optical …

Fluorescence microscopy provides an efficient and unique approach to study fixed and
living cells because of its versatility, specificity, and high sensitivity. Fluorescence …

Fluorescence lifetime imaging (FLIM) is a key fluorescence microscopy technique to map the
environment and interaction of fluorescent probes. It can report on photophysical events that …

The field of biomedical optics has matured rapidly over the last decade and is poised to
make a significant impact on patient care. In particular, wide-field (typically> 5 cm), planar …

Since the earliest examination of cellular structures, biologists have been fascinated by
observing cells using light microscopy. The advent of fluorescent labeling technologies plus …

▪ Abstract The interaction of light within tissue has been used to recognize disease since the
mid-1800s. The recent developments of small light sources, detectors, and fiber optic probes …

Abbreviations: ACF, aberrant crypt foci; ALA, 5-aminolevulinic acid; AIS4PC, tetrasulfonated
chloroaluminum phthalocyanine; antiCEA MoAb, anticarcinoembryonic antigen; BBC, basal …

Three dimensional (3D) tissue models of the human skin are probably the most developed
and understood in vitro engineered constructs. The motivation to accomplish organotypic …