Molecularly stimuli-responsive self-assembled peptide nanoparticles for targeted imaging and therapy

Y Zhou, Q Li, Y Wu, X Li, Y Zhou, Z Wang, H Liang… - ACS …, 2023 - ACS Publications
Self-assembly has emerged as an extensively used method for constructing biomaterials
with sizes ranging from nanometers to micrometers. Peptides have been extensively …

“Combo” nanomedicine: co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

JA Kemp, MS Shim, CY Heo, YJ Kwon - Advanced drug delivery reviews, 2016 - Elsevier
The dynamic and versatile nature of diseases such as cancer has been a pivotal challenge
for developing efficient and safe therapies. Cancer treatments using a single therapeutic …

Micelles with ultralow critical micelle concentration as carriers for drug delivery

Y Lu, Z Yue, J Xie, W Wang, H Zhu, E Zhang… - Nature biomedical …, 2018 - nature.com
Conventional micellar carriers disassemble into free surfactants when diluted at
concentrations below the critical micelle concentration (CMC). This limits the bioavailability …

On virus growth and form

R Zandi, B Dragnea, A Travesset, R Podgornik - Physics Reports, 2020 - Elsevier
We review approaches aimed at deciphering the physical mechanisms responsible for viral
structure and assembly. We discuss the basic principles of condensed matter physics …

Adeno-associated virus (AAV) vectors in cancer gene therapy

JL Santiago-Ortiz, DV Schaffer - Journal of Controlled Release, 2016 - Elsevier
Gene delivery vectors based on adeno-associated virus (AAV) have been utilized in a large
number of gene therapy clinical trials, which have demonstrated their strong safety profile …

Equilibrium mechanisms of self-limiting assembly

MF Hagan, GM Grason - Reviews of modern physics, 2021 - APS
Self-assembly is a ubiquitous process in synthetic and biological systems, broadly defined
as the spontaneous organization of multiple subunits (macromolecules, particles, etc.) into …

Programming stimuli-responsive behavior into biomaterials

BA Badeau, CA DeForest - Annual review of biomedical …, 2019 - annualreviews.org
Stimuli-responsive materials undergo triggered changes when presented with specific
environmental cues. These dynamic systems can leverage biological signals found locally …

Gene therapy for regenerative medicine

H Hosseinkhani, AJ Domb, G Sharifzadeh, V Nahum - Pharmaceutics, 2023 - mdpi.com
The development of biological methods over the past decade has stimulated great interest in
the possibility to regenerate human tissues. Advances in stem cell research, gene therapy …

Enzyme responsive drug delivery system based on mesoporous silica nanoparticles for tumor therapy in vivo

Y Liu, X Ding, J Li, Z Luo, Y Hu, J Liu, L Dai… - …, 2015 - iopscience.iop.org
To reduce the toxic side effects of traditional chemotherapeutics in vivo, we designed and
constructed a biocompatible, matrix metalloproteinases (MMPs) responsive drug delivery …

Is viral vector gene delivery more effective using biomaterials?

Y Wang, KF Bruggeman, S Franks… - Advanced …, 2021 - Wiley Online Library
Gene delivery has been extensively investigated for introducing foreign genetic material into
cells to promote expression of therapeutic proteins or to silence relevant genes. This …