Self tolerance loss is fundamental to autoimmunity. While understanding of immune
regulation is expanding rapidly, the mechanisms causing loss of tolerance in most …

Granulomatous meningoencephalomyelitis, necrotizing meningoencephalitis, and
necrotizing leukoencephalitis are common inflammatory conditions of the canine central …

BACKGROUND: Common autoimmune disorders tend to coexist in the same subjects and to
cluster in families. METHODS: We performed a cross-sectional multicenter study of 3286 …

Multiple sclerosis (MS) is more prevalent in females than males, and this female
predominance is increasing as time goes by. Additionally, gender appears to play critical …

Objective To understand the nature of genetic and environmental susceptibility to multiple
sclerosis (MS) and, by extension, susceptibility to other complex genetic diseases …

We briefly survey the concept of autoimmunity and nominate the range of autoimmune
diseases that include multisystemic and organ-specific disorders, and cite prevalences of …

Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease with a rapidly
increasing female gender bias. MS prevalence decreases with increasing sunlight …

Autoimmune diseases are caused by the overactivity of the immune system towards self-
constituents. Risk factors of autoimmune diseases are multiple and include genetic …

Background: Although the histopathologic features of necrotizing meningoencephalitis
(NME) have been described previously, little information is available concerning the …

Background: Multiple sclerosis (MS) is a complex neurologic disease of unknown etiology
and inheritance pattern, but with increasing incidence among females. The study of …