Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …

Abstract N 7-methylguanosine (m7G), one of the most prevalent RNA modifications, has
recently attracted significant attention. The m7G modification actively participates in …

Background Biliary tract cancers, which arise from the intrahepatic or extrahepatic bile ducts
and the gallbladder, generally have a poor prognosis and are rising in incidence worldwide …

We performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA)
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …

Background and Objectives: The tumor microenvironment has been widely implicated in
tumorigenesis because it harbors tumor cells that interact with surrounding cells through the …

Cancer cells selectively promote translation of specific oncogenic transcripts to facilitate
cancer survival and progression, but the underlying mechanisms are poorly understood …

Cholangiocarcinoma is the second most common primary liver cancer. Its incidence is low in
the Western world but is rising globally. Surgery, chemotherapy and radiation therapy have …

In the past 5 years, important advances have been made in the scientific understanding and
clinical management of cholangiocarcinoma (CCA). The cellular immune landscape of CCA …

Intrahepatic cholangiocarcinoma (iCCA) is a highly heterogeneous cancer with limited
understanding of its classification and tumor microenvironment. Here, by performing single …

Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …