Small-molecule antivirals can be used as chemical probes to stabilize transitory
conformational stages of viral target proteins, facilitating structural analyses. Here, we …

The Mononegavirales, or non-segmented negative-sense RNA viruses (nsNSVs), includes
significant human pathogens, such as respiratory syncytial virus, parainfluenza virus …

Abstract The Nipah virus (NiV), a member of the Paramyxoviridae family, is notorious for its
high fatality rate in humans. The RNA polymerase machinery of NiV, comprising the large …

Nipah virus (NiV) is a bat-borne, zoonotic RNA virus that is highly pathogenic in humans.
The NiV polymerase, which mediates viral genome replication and mRNA transcription, is a …

Nipah virus, a member of the Paramyxoviridae family, is a highly pathogenic nonsegmented,
negative-sense RNA virus (nsNSV) which causes severe neurological and respiratory …

The transcription and replication processes of non-segmented, negative-strand RNA viruses
(nsNSVs) are catalyzed by a multi-functional polymerase complex composed of the large …

Nipah virus is a highly virulent zoonotic paramyxovirus causing severe respiratory and
neurological disease. Despite its lethality, there is no approved treatment for Nipah virus …

Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory infections for
which effective treatment options remain limited. Herein, we employed a computational …

Small molecules that specifically target viral polymerases—crucial enzymes governing viral
genome transcription and replication—play a pivotal role in combating viral infections …

Respiratory syncytial virus is a common cause of respiratory infection that often leads to
hospitalization of infected younger children and older adults. RSV is classified into two …