Due to the advent of high throughput sequencing techniques and structural genomic
projects, the number of gene and protein sequences has been ever increasing …

Structural genomics projects have solved many new structures with unknown functions. One
strategy to investigate the function of a structure is to computationally find the functionally …

Background Prediction of ligand binding sites is important to elucidate protein functions and
is helpful for drug design. Although much progress has been made, many challenges still …

Proteins often work as oligomers or multimers in vivo. Therefore, elucidating their oligomeric
or multimeric form (quaternary structure) is crucially important to ascertain their function. X …

The alpha-1 subunit (CACNA1 family) of L-type voltage-gated calcium channels (LTCCs)
play significant roles in brain function and neuropsychiatric disorders. Transcription of …

Oligomers of G protein-coupled receptors (GPCRs) are closely related to their biochemical
and biological functions and have been conserved during the course of molecular evolution …

Les méthodes de criblage virtuel sont largement utilisées dans le processus de conception
de médicaments afin de réduire le nombre de composés à tester expérimentalement …

Computational methods are being employed to predict active binding sites of enzymes. The
principal reasons are that the pace of discovery of new proteins is increasing, outpacing the …