Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment
Tumor-associated macrophages are an abundant cell type in the tumor microenvironment.
These macrophages serve as a promising target for treatment of cancer due to their roles in …
These macrophages serve as a promising target for treatment of cancer due to their roles in …
The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer
The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution
JC Stanford, C Young, D Hicks… - The Journal of …, 2014 - Am Soc Clin Investig
Breast cancers that occur in women 2–5 years postpartum are more frequently diagnosed at
metastatic stages and correlate with poorer outcomes compared with breast cancers …
metastatic stages and correlate with poorer outcomes compared with breast cancers …
The role of TAM family receptors in immune cell function: implications for cancer therapy
M Paolino, JM Penninger - Cancers, 2016 - mdpi.com
The TAM receptor protein tyrosine kinases—Tyro3, Axl, and Mer—are essential regulators of
immune homeostasis. Guided by their cognate ligands Growth arrest-specific gene 6 (Gas6) …
immune homeostasis. Guided by their cognate ligands Growth arrest-specific gene 6 (Gas6) …
Role of vitamin K-dependent factors protein S and GAS6 and TAM receptors in SARS-CoV-2 infection and COVID-19-associated immunothrombosis
The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6
(GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of …
(GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of …
MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system
JM Huelse, DM Fridlyand, S Earp, D DeRyckere… - Pharmacology & …, 2020 - Elsevier
The receptor tyrosine kinase MERTK is aberrantly expressed in numerous human
malignancies, and is a novel target in cancer therapeutics. Physiologic roles of MERTK …
malignancies, and is a novel target in cancer therapeutics. Physiologic roles of MERTK …
Migrating interneurons secrete fractalkine to promote oligodendrocyte formation in the developing mammalian brain
During development, newborn interneurons migrate throughout the embryonic brain. Here,
we provide evidence that these interneurons act in a paracrine fashion to regulate …
we provide evidence that these interneurons act in a paracrine fashion to regulate …
Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery
Age-dependent alterations in microglia behavior have been implicated in
neurodegeneration and CNS injuries. Here, we compared the transcriptional profiles of …
neurodegeneration and CNS injuries. Here, we compared the transcriptional profiles of …
Yes-associated protein 1 (YAP1) promotes human gallbladder tumor growth via activation of the AXL/MAPK pathway
M Li, J Lu, F Zhang, H Li, B Zhang, X Wu, Z Tan… - Cancer letters, 2014 - Elsevier
The transcriptional coactivator Yes-associated protein 1 (YAP1), a key regulator of cell
proliferation and organ size in vertebrates, has been implicated in various malignancies …
proliferation and organ size in vertebrates, has been implicated in various malignancies …
Role of apoptotic cell clearance in pneumonia and inflammatory lung disease
DJ Zheng, M Abou Taka, B Heit - Pathogens, 2021 - mdpi.com
Pneumonia and inflammatory diseases of the pulmonary system such as chronic obstructive
pulmonary disease and asthma continue to cause significant morbidity and mortality …
pulmonary disease and asthma continue to cause significant morbidity and mortality …