[HTML][HTML] Membrane proteins structures: A review on computational modeling tools
Abstract Background Membrane proteins (MPs) play diverse and important functions in
living organisms. They constitute 20% to 30% of the known bacterial, archaean and …
living organisms. They constitute 20% to 30% of the known bacterial, archaean and …
Comprehensive review and empirical analysis of hallmarks of DNA-, RNA-and protein-binding residues in protein chains
Proteins interact with a variety of molecules including proteins and nucleic acids. We review
a comprehensive collection of over 50 studies that analyze and/or predict these interactions …
a comprehensive collection of over 50 studies that analyze and/or predict these interactions …
SpotOn: high accuracy identification of protein-protein interface hot-spots
We present SpotOn, a web server to identify and classify interfacial residues as Hot-Spots
(HS) and Null-Spots (NS). SpotON implements a robust algorithm with a demonstrated …
(HS) and Null-Spots (NS). SpotON implements a robust algorithm with a demonstrated …
PPI-hotspotID: A Method for Detecting Protein-Protein Interaction Hot Spots from the Free Protein Structure
YC Chen, K Sargsyan, JD Wright, YH Chen, YS Huang… - eLife, 2024 - elifesciences.org
Experimental detection of residues critical for protein-protein interactions (PPI) is a
timeconsuming, costly, and labor-intensive process. Hence, high-throughput PPI-hot spot …
timeconsuming, costly, and labor-intensive process. Hence, high-throughput PPI-hot spot …
Protein-protein interface hot spots prediction based on a hybrid feature selection strategy
Background Hot spots are interface residues that contribute most binding affinity to protein-
protein interaction. A compact and relevant feature subset is important for building machine …
protein interaction. A compact and relevant feature subset is important for building machine …
SARS-CoV-2 membrane protein: from genomic data to structural new insights
C Marques-Pereira, MN Pires, RP Gouveia… - International Journal of …, 2022 - mdpi.com
Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) is composed of four
structural proteins and several accessory non-structural proteins. SARS-CoV-2's most …
structural proteins and several accessory non-structural proteins. SARS-CoV-2's most …
PPI-HotspotDB: Database of Protein–Protein Interaction Hot Spots
YC Chen, YH Chen, JD Wright… - Journal of Chemical …, 2022 - ACS Publications
Single-point mutations of certain residues (so-called hot spots) impair/disrupt protein–
protein interactions (PPIs), leading to pathogenesis and drug resistance. Conventionally, a …
protein interactions (PPIs), leading to pathogenesis and drug resistance. Conventionally, a …
A machine learning approach for hot-spot detection at protein-protein interfaces
R Melo, R Fieldhouse, A Melo, JDG Correia… - International journal of …, 2016 - mdpi.com
Understanding protein-protein interactions is a key challenge in biochemistry. In this work,
we describe a more accurate methodology to predict Hot-Spots (HS) in protein-protein …
we describe a more accurate methodology to predict Hot-Spots (HS) in protein-protein …
dbAMEPNI: a database of alanine mutagenic effects for protein–nucleic acid interactions
Protein–nucleic acid interactions play essential roles in various biological activities such as
gene regulation, transcription, DNA repair and DNA packaging. Understanding the effects of …
gene regulation, transcription, DNA repair and DNA packaging. Understanding the effects of …
dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions
Abstract Background Protein-protein interactions (PPIs) play important roles in biological
functions. Studies of the effects of mutants on protein interactions can provide further …
functions. Studies of the effects of mutants on protein interactions can provide further …