Background: Nucleoside phosphorylases catalyze the reversible phosphorolysis of
pyrimidine and purine nucleosides in the presence of phosphate. They are relevant to the …

Nucleosides primarily consist of a nitrogenous base (nucleobase), which is either a purine
base or a pyrimidine base and a five-carbon sugar (pentose). The base and sugar are …

Inhibition of Thymidine phosphorylase (TP) is continuously studied for the design and
development of new drugs for the treatment of neoplastic diseases. As a part of our effort to …

The development and formation of X-ray crystallography of macromolecules, or protein
crystallography, is one of the most important achievements of science in the 20th century …

Pyrimidine-nucleoside phosphorylase catalyzes the phosphorolytic cleavage of thymidine
and uridine with equal activity. Investigation of this protein is essential for anticancer drug …

Background Coumarins are secondary metabolites from the phenylpropanoid-type
biosynthesis in higher plants. A plethora of potential phytopharmacological activities have …

Using a molecular dynamics method, the state of the dimeric thymidine phosphorylase
molecule from Escherichia coli in a complex with noncompetitive enzyme inhibitor 3' …

Pyrimidine nucleoside phosphorylases, which are widely used in the biotechnological
production of nucleosides, have different substrate specificity for pyrimidine nucleosides. An …

The emergence and development of X-ray crystallography of macromolecules or protein
crystallography is one of the outstanding scientific achievements in the 20th century. The …

Изобретение относится к области биохимии. Предложен неконкурентный ингибитор
тимидинфосфорилаз пептидной природы H-Trp-Met (О 2)-Phe-NH 2. Изобретение …